MP31-08 EXOGENOUS TESTOSTERONE THERAPY IN MEN WITH KLINEFELTER SYNDROME NEGATIVELY IMPACTS SPERM RETRIEVAL

You have accessJournal of UrologyInfertility: Therapy (MP31)1 Sep 2021MP31-08 EXOGENOUS TESTOSTERONE THERAPY IN MEN WITH KLINEFELTER SYNDROME NEGATIVELY IMPACTS SPERM RETRIEVAL Caroline Kang, Nahid Punjani, and Peter N. Schlegel KangCaroline Kang More articles by this author , PunjaniNahid Punjani SchlegelPeter View All Author Informationhttps://doi.org/10.1097/JU.0000000000002035.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Men with Klinefelter syndrome (KS) classically testicular failure are at risk for both testosterone (T) deficiency infertility. T replacement therapy (TRT) often is initiated in adolescence its potential neurodevelopmental benefits. Unfortunately, exogenous has a defined adverse effect on spermatogenesis. We sought examine the sperm retrieval men KS. METHODS: KS undergoing microdissection extraction (mTESE) performed single surgeon between 1995-2020 were reviewed. Demographic data hormone-modifying agents, such as human chorionic gonadotropin (hCG) aromatase inhibitors (AI), administered prior mTESE obtained. History or current use was recorded categorized based formulation into either short- (gel foam) long-acting (pellets injection) groups. Descriptive statistics SRR reported. Patients incomplete hormone well repeat procedures same patient excluded. RESULTS: A total 290 retrievals during study period. Fourteen had history TRT currently using time (Table 1). Median age 34 years (interquartile range (IQR) 31–36), median testis size 1.3 mL (IQR 1.0–1.5). Five remote up 2 mTESE, received hCG AI retrieval. Of these, all five (100%) successful In receiving topical concurrent and/or only two (40%) No continuous delivery (e.g., injectable pellet) identified mTESE. CONCLUSIONS: Exogenous common patients. Long-acting (e.g. implantable T) suppresses production production, predisposing failed However, monotherapy short-acting topical) formulations together AIs can maintain endogenous spermatogenesis; consistent men. Additional prospective trials needed elucidate effects Source Funding: CK NP supported part Frederick J. Theresa Dow Wallace Fund New York Community Trust © 2021 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e557-e558 Advertisement Copyright & Permissions© Inc.MetricsAuthor Information Expand Loading ...